Best Blockchain (2026)
Ranked picks for blockchain. No "it depends."
Brownie
Python's answer to Ethereum development. All the smart contract power, none of the JavaScript fatigue.
Full Rankings
Brownie
Nice PickPython's answer to Ethereum development. All the smart contract power, none of the JavaScript fatigue.
Why we picked it
Brownie is the definitive Python framework for Ethereum development, offering a complete toolchain from compilation to testing to deployment. Its pytest integration and built-in debugger give it a clear edge over Hardhat for Python developers, while Ganache-based local forking is more reliable than Anvil. The only reason to pick Hardhat is if you're forced into JavaScript — otherwise, Brownie is faster to write and easier to debug.
→ Use it when you want to write Ethereum smart contracts in Python and need a framework that handles compilation, testing, and deployment without the JavaScript overhead.
Pros
- +Python-based scripting makes contract interaction intuitive for Python devs
- +Built-in support for Ganache and Web3.py streamlines local testing
- +Automates compilation and deployment, reducing boilerplate code
Cons
- -Limited ecosystem compared to JavaScript-based tools like Hardhat
- -Can be slower for large projects due to Python's overhead
Python's answer to smart contract development. All the blockchain headaches, now with fewer excuses.
Why we picked it
Ape Framework is the only serious Python-native smart contract framework, but it's held back by a smaller ecosystem and slower adoption than Foundry. Its plugin system and Vyper support are genuine differentiators for Python shops, yet Foundry's speed and Solidity-first tooling make it the default for most teams. Ape wins if you need Vyper or Python integration, loses everywhere else.
→ Use it when your team is Python-only, you need first-class Vyper support, or you want a plugin architecture to customize your workflow beyond what Foundry offers.
Pros
- +Leverages Python's ecosystem for testing and tooling
- +Modular plugin system for custom workflows
- +Built-in support for multiple EVM-compatible chains
- +Integrated project management and contract compilation
Cons
- -Python dependency hell can creep in
- -Still requires deep blockchain knowledge despite the abstraction
Head-to-head comparisons
Missing a tool?
Email nice@nicepick.dev and I'll add it to the rankings.