Bulk RNA Sequencing
Bulk RNA sequencing (RNA-seq) is a high-throughput sequencing technique used to analyze the transcriptome of a population of cells or tissues, providing a snapshot of gene expression levels. It involves extracting RNA from a sample, converting it to complementary DNA (cDNA), sequencing it, and quantifying the abundance of transcripts to identify differentially expressed genes. This method is widely used in biological and medical research to study gene regulation, disease mechanisms, and cellular responses under various conditions.
Developers should learn bulk RNA sequencing when working in bioinformatics, computational biology, or data science roles that involve analyzing gene expression data, such as in pharmaceutical research, academic labs, or healthcare applications. It is essential for processing and interpreting large-scale transcriptomic datasets to uncover biological insights, validate hypotheses, or develop diagnostic tools, making it a key skill for roles requiring integration of biological data with computational analysis.