ChIP-Seq
ChIP-Seq (Chromatin Immunoprecipitation Sequencing) is a molecular biology technique used to analyze protein-DNA interactions across the genome. It combines chromatin immunoprecipitation (ChIP) with high-throughput DNA sequencing to identify binding sites of transcription factors, histone modifications, or other DNA-associated proteins. This method provides genome-wide maps of protein-DNA interactions with high resolution and specificity.
Developers should learn ChIP-Seq when working in bioinformatics, genomics, or computational biology to analyze epigenetic regulation, gene expression, and chromatin structure. It is essential for projects involving transcription factor binding studies, histone modification profiling, or epigenetic research in fields like cancer biology, developmental biology, and drug discovery. Mastery enables handling large-scale sequencing data to uncover regulatory mechanisms.