PySide
PySide is a Python binding for the Qt framework, enabling developers to create cross-platform desktop and mobile applications with native-looking GUIs. It provides access to Qt's extensive set of libraries for UI design, networking, multimedia, and more, allowing Python developers to build robust applications without needing C++ knowledge. PySide is officially supported by The Qt Company and is part of the Qt for Python project.
Developers should learn PySide when they need to build desktop applications in Python that require a professional, native-looking GUI across Windows, macOS, and Linux. It's ideal for creating tools, utilities, or complex applications like data analysis dashboards, media players, or business software where Qt's rich widget set and performance are beneficial. Compared to other Python GUI libraries, PySide offers better integration with modern Qt features and commercial support options.